Melatonin-SR
Melatonin-SR
Melatonin-SR
Melatonin-SR
Melatonin-SR
Melatonin-SR
Melatonin-SR
Melatonin-SR
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Sleep Aid

Melatonin-SR

Regular price
₹500.00
Sale price
₹500.00
Regular price
₹500.00
Sold out
Unit price
per 
FWE.56.3
18.Jul.2024
18.Jul.2025

SUGGESTED USE

Adults take 1 capsule, one hour prior to bedtime with a glass of water or as suggested by your Healthcare Professional.

Nutrition Facts

Certificate of Analysis

Product Information

Unived's Melatonin-SR is a novel sleep solution containing sustained-release melatonin combined with L-theanine and Magnesium glycinate. This precise formulation is designed to support healthy sleep cycles and enhance both sleep quality and duration and more. As the first product in India to feature a slow-release melatonin. Melatonin-SR provides a comprehensive means of meeting all of your sleep health objectives.

Key Benefits

  • Long-acting Melatonin.
  • Helps in sleep cycle regulation.
  • Restores natural sleep patterns.
  • Helps sustain 8 hours of sleep.
  • Helps combat oxidative stress.
  • Supports cognitive and immune health.
  • Helps regulate insulin secretion, and improve glucose homeostasis.

Ingredient Information

  • L-Theanine (from Green Tea Extract) – 100mg
  • Magnesium Glycinate – 15.88mg
  • Melatonin SR Granules – 11.12mg
Importance of Sleep:

Sleep is an evolutionarily conserved behavioral state in human beings [1]. Getting adequate, high-quality sleep is vital for health, cognition, and daytime performance. Most adults need 7-9 hours of sleep per night to function optimally as sleep plays a crucial role in maintaining neurological, physiological, and psychological health throughout our lives. Chronic sleep disorders have been associated with conditions like coronary heart disease and depression, leading to a potential reduction in the long term [4]. The necessary or proper quantity and quality of sleep maintains brain, heart, and immune health as well as aiding in memory consolidation and restoration of brain function [2]. Humans normally experience sleep cyclically once a day due to a tightly regulated circadian control.

The relationship between Sleep and Melatonin

Melatonin is a hormone produced naturally in the body at the center of the brain in an area called the pineal gland which is about the size of a pea and regulates sleep-wake cycles [2]. Melatonin works to maintain your body's circadian rhythm by causing drowsiness and lowering body temperature at night. As daylight fades at night, the body produces melatonin, triggering a cascade of effects that make you sleepy. Melatonin levels remain elevated throughout the night, then drop off towards morning as exposure to light increases, signaling the body to become alert and awake [4].

Disruptions to this cycle can lead to decreased melatonin which is associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm-related sleep disorders sleep disorders, and other issues. For example, lack of exposure to natural light during the day or exposure to blue light from electronics at night can inhibit melatonin production, making it harder to fall asleep. Melatonin supplements may help reset your circadian clock, especially for those with circadian rhythm sleep-wake disorders or who do shift work [1]. Moreover, the production of the hormone decreases with age which results in the increased frequency of poor sleep quality. It has been suggested that melatonin deficit is at least partly responsible for sleep disorders in the elderly [1].

Melatonin and supplements

Melatonin plays an important role in regulating sleep-wake cycles and maintaining a proper circadian rhythm. By understanding how melatonin works and following good sleep hygiene practices, you can support healthy sleep and daytime wellness.

Melatonin supplements can be useful for certain sleep disorders and irregular sleep-wake cycles. Melatonin supplements provide an additional dose of the hormone to help reset your body's internal clock and establish a normal sleep pattern. Studies show melatonin can help people with these disorders fall asleep earlier, sleep longer, and feel more awake during the day [5]. In summary, melatonin supplements are considered very safe for short-term use and can be effective for certain sleep-wake disorders and jet lag. However, you should always check with your doctor before starting any supplement to determine if it's appropriate and the proper dosage for you based on your medical history and condition.

What is a slow-release melatonin supplement? And its advantages?

Slow-release melatonin is a type of melatonin supplement that gradually releases the hormone into the body over a longer period. This differs from fast-acting melatonin supplements, which release their full dose of melatonin into the body quickly.

When melatonin is released into the body all at once, as in fast-acting supplements, it can cause a sudden spike in melatonin levels that drops off quickly as the supplement is absorbed. This can potentially disrupt sleep patterns and cause grogginess the next day. Rapid metabolism of melatonin impacts the long-term bioavailability in the plasma and has a short half-life of 40-60 minutes.

In contrast, slow-release melatonin formulations are designed to break down gradually and release melatonin over several hours. This helps maintain a steady concentration of the hormone over the course of the night, more closely mimicking the body's natural release of melatonin.

The main advantages of slow-release melatonin are that it can promote more restful sleep and less interruptions throughout the night. By maintaining a consistent level of melatonin, slow-release supplements may help you fall asleep faster and stay asleep longer. They can also reduce the unwanted daytime sleepiness that some people experience with fast-acting melatonin.

Overall, slow-release melatonin is thought to provide a more natural regulation of melatonin levels and a more consistent sleep-wake cycle compared to fast-acting melatonin supplements.

References:

1. Gandhi, Avni V., et al. "Melatonin is required for the circadian regulation of sleep." Neuron 85.6 (2015): 1193-1199.

2. Vasey, Clayton, Jennifer McBride, and Kayla Penta. "Circadian rhythm dysregulation and restoration: the role of melatonin." Nutrients 13.10 (2021): 3480.

3. Garcia, Lizeth Soto. "Melatonin and its Effects: The Truth Behind this Popular Supplement."

4. Zisapel, Nava. "New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation." British journal of pharmacology 175.16 (2018): 3190-3199.

5. Masters, Alina, et al. "Melatonin, the hormone of darkness: from sleep promotion to ebola treatment." Brain disorders & therapy 4.1 (2014).

6. Nielsen, Forrest H. "Relation between magnesium deficiency and sleep disorders and associated pathological changes." Modulation of Sleep by Obesity, Diabetes, Age, and Diet. Academic Press, 2015. 291-296.

Unived’s Melotonin-SR is formulated with Melotonin slow-release Granules standardized to 5mg Melatonin, 100 mg L-Theanine from Green Tea extract, and, Magnesium glycinate.

Mode of Action:

  • Melotonin-SR offers a unique release profile with a larger proportion available as immediate-release (within 1 hour) which aids in the process of falling asleep and is followed by a consistent release over the next 6 hours which contributes to a continuous sound sleep. This unique profile ensures consistent sustained and sound sleep for 8 hours without side effects. Melotonin-SR provides a unique sustained-release profile in granular form, with adequate melatonin release. This enables the individual to fall asleep within the first hour. Subsequent continuous release then maintains sleep. The melatonin release then tapers, allowing the individual to complete a satisfactory sleep cycle without side effects.
  • L-Theanine: Improve sleep quality through inhibitory neurotransmitters [7].
  • Magnesium glycinate: Magnesium helps promote sleep through its effects on melatonin secretion, GABA, and glutamate neurotransmitter activity all of which contribute to the body's natural sleep mechanisms [6]. It also promotes relaxation and makes one feel less tired which may induce sleep. Mg with L-theanine potentiates the effect of L-theanine by working synergistically to sleep by boosting slow-brain waves, regulating brain electrical activity, and increasing neurotransmitter and GABA receptor levels [7].

References:

7. Dasdelen, Muhammed Furkan, et al. "A novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity." Frontiers in Nutrition 9 (2022): 570.

What is the recommended usage of Melatonin-SR?

The recommended dosage for adults is to take one capsule approximately one hour prior to bedtime with a full glass of water, unless otherwise directed by a healthcare professional. Do not exceed the recommended daily dosage.

10. Can it be combined with Magnesium supplements?

Magnesium alone may help with relaxation and sleep if not severely sleep-deprived. Melatonin addresses the underlying causes of sleep issues and is preferable to promote healthy sleep-wake cycles. Melatonin-SR contains magnesium. Consult your doctor to determine the best option.

How long should I take this supplement?

We recommend taking the supplement for 3 to 6 months. After this, you can taper off use and then reevaluate your sleep patterns without the supplement for several weeks. Resume supplement use if needed.

Can Melatonin-SR be taken during the day?

Melatonin-SR is intended for nighttime use before bedtime. Daytime administration may cause drowsiness and interfere with daily activities due to the supplement's pharmacologic effects. If you are a night shift worker, you may consider taking the supplement 30 minutes to one hour before going to bed during your daytime.

When will the effects of this supplement be noticed?

The onset of action for Melatonin-SR is approximately one hour to aid the sleep onset process. For the following 6 hours, it works consistently to promote continuous, quality sleep. Refer to the product information for additional details on the mechanism of action.

Will melatonin cause extended drowsiness?

Melatonin-SR is a slow-release melatonin supplement. Its effects are designed to last approximately six hours before gradually tapering off. This extended-release formulation is intended to help induce healthy sleep while avoiding unintended daytime drowsiness upon waking.

Can it be used during pregnancy or breastfeeding?

We do not recommend using Melatonin during pregnancy or breastfeeding. Consult your physician before using any supplements during these times.

Is this supplement addictive?

While Melatonin itself is not addictive as it mimics an endogenous hormone, supplement use may become habitual over time. We advise taking periodic breaks after long-term use to re-evaluate sleep patterns without supplementation.

Is the supplement safe and what are the potential side effects?

Melatonin is generally safe when used as directed. Potential side effects may include dizziness, mood changes, gastrointestinal disturbances, or headaches if excessively dosed. Always follow recommended dosing instructions.

Should other supplements or medications be avoided while using this?

Some medications can interact with Melatonin by altering levels. Consult your healthcare provider before use if taking medications for conditions like hypertension, diabetes, immunosuppression, or mental health.

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Sleep Aid

Melatonin-SR

Regular price
₹500.00
Sale price
₹500.00
Regular price
₹500.00
Sold out
Unit price
per 
FWE.56.3
18.Jul.2024
18.Jul.2025

SUGGESTED USE

Adults take 1 capsule, one hour prior to bedtime with a glass of water or as suggested by your Healthcare Professional.