SUGGESTED USE
Adults take 1 capsule daily post lunch, with a glass of water.
Product Information
Unived’s Alpha-Lipoic Acid capsules are a blend of research-based effective dosage of Alpha-Lipoic Acid with supportive minerals like Zinc, Calcium, and Magnesium to support the body with potent antioxidant benefits, liver protection, effective glucose disposal, and boost overall cellular energy. Unived’s ALA may be a beneficial dietary supplement for those concerned about a more complete antioxidant defense system and proper glucose metabolism.
Alpha-Lipoic Acid (ALA) is a natural organic compound produced in the body in small amounts where it acts as a potent antioxidant and helps in converting glucose into energy. Alpha-Lipoic Acid is mainly involved in preventing cellular damage from oxidative stress and cellular energy production by effective carbohydrate, protein, and fat metabolism.
Scientific studies indicate that Alpha-Lipoic Acid exerts many health benefits restoring insulin sensitivity, protecting the liver against oxidative damage, improving endothelial function, anti-inflammatory actions, and cognitive support [1].
References
1. Gomes, Marilia Brito, and Carlos Antonio Negrato. "Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases." Diabetology & metabolic syndrome 6.1 (2014): 1-18.
Key Benefits
- Helps reduce oxidative stress and prevent oxidative damage.
- Reduces insulin resistance and regulates blood glucose.
- Supports and maintains overall liver health.
- Plays an important role in energy metabolism.
Ingredient Information
- Alpha Lipoic Acid – 300mg
- Algas calcareas – 116mg
- Zinc Citrate – 44mg
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ALA serves as a unique biological antioxidant that neutralizes free radicals generated by oxidative stress due to its unique sulfur-containing structure [8]. The amount of ALA produced by the body decreases with age along with a decline in the synthesis and recycling of other key nutrients like glutathione, and coenzyme Q10, leaving the body vulnerable to oxidative damage [7] [6].
Supplementing ALA may be necessary to maintain adequate levels and regenerate other antioxidants and boost the body’s overall antioxidant capacity against numerous complications and diseases that are associated with impaired energy utilization and increased oxidative stress, including type 2 diabetes, neurological diseases, and cardiovascular disease.
References
3. García-Sánchez, Andrés, Alejandra Guillermina Miranda-Díaz, and Ernesto Germán Cardona-Muñoz. "The role of oxidative stress in physiopathology and pharmacological treatment with pro-and antioxidant properties in chronic diseases." Oxidative Medicine and Cellular Longevity 2020 (2020).
6. Oregon State University. "Lipoic Acid Explored As Anti-aging Compound." ScienceDaily. ScienceDaily, 18 May 2007. www.sciencedaily.com/releases/2007/05/070517130823.htm
7. Packer, Lester, Eric H. Witt, and Hans Jürgen Tritschler. "Alpha-lipoic acid as a biological antioxidant." Free radical biology and medicine 19.2 (1995): 227-250.
8. Data, Product. "Alpha-lipoic acid." Arzneimittelforschung 45 (1995): 872-874.
9. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017;2017:8416763. doi: 10.1155/2017/8416763. Epub 2017 Jul 27. PMID: 28819546; PMCID: PMC5,551541.
Alpha Lipoic acid exerts multiple modes of action.
- Antioxidant activity: Neutralizes and scavenges free radicals like singlet oxygen, superoxides, peroxyl, and hydroxyl radicals, hypochlorite, and peroxynitrite. It regenerates other antioxidants such as glutathione, vitamin C, vitamin E, and coenzyme Q10 [11] [14]. ALA also can chelate metals and eliminate them which can produce an antioxidant effect [10].
- Glucose metabolism and Insulin Resistance: ALA decreases insulin resistance and increases insulin sensitivity and effective glucose utilization [12] [13].
- Liver Protection: ALA inhibits inflammatory mediators like Nitric oxide and TNF-α in the injured liver, thus exhibiting its anti-inflammatory action [15]. Alleviates NAFLD progression associated with T2DM and triglyceride accumulation in the liver [16].
- Energy production: It plays a pivotal role in cellular metabolism by acting as a coenzyme in energy production [17].
References
2. Markiewicz-Górka, Iwona, et al. "Alleviating effect of α-lipoic acid and magnesium on cadmium-induced inflammatory processes, oxidative stress and bone metabolism disorders in Wistar rats." International journal of environmental research and public health 16.22 (2019): 4483.
4. Park, Sungmi, et al. "Physiological effect and therapeutic application of alpha lipoic acid." Current medicinal chemistry 21.32 (2014): 3636-3645.
5. Du, Gang, et al. "Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction." EMBO reports 21.8 (2020): e49583.
10. El Barky AR, Hussein SA and Mohamed TM. The Potent Antioxidant Alpha Lipoic Acid. J Plant Chem and Ecophysiol. 2017; 2(1): 1016.
11. Gorąca, Anna, et al. "Lipoic acid–biological activity and therapeutic potential." Pharmacological Reports 63.4 (2011): 849-858.
12. Lee, Woo Je, et al. "α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle." Biochemical and biophysical research communications 332.3 (2005): 885-891.
13. Evans, Joseph L., and Ira D. Goldfine. "α-Lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes." Diabetes technology & therapeutics 2.3 (2000): 401-413.
14. Moini, Hadi, Lester Packer, and Nils-Erik L. Saris. "Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid." Toxicology and applied pharmacology 182.1 (2002): 84-90.
15. https://clinicaltrials.gov/ct2/show/NCT04475276#wrapper
16. Ko, Chih‐Yuan, et al. "Alpha‐lipoic acid alleviates NAFLD and triglyceridthe e accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats." Food science & nutrition 9.5 (2021): 2733-2742.
17. Krämer, Klaus, and Lester Packer. "R-α-lipoic acid." Nutraceuticals in health and disease prevention (2001): 141-174.
Does Alpha-Lipoic acid interact with other medicines or supplements?
Avoid using alpha-lipoic acid with other medicines or supplements that can also lower blood sugar, which include Metformin, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.
Can Alpha-Lipoic Acid supplement taken if I’m pregnant or breastfeeding?
Do not use this product without medical advice if you are pregnant or breastfeeding.
How to take Alpha-Lipoic acid supplement?
Adults take 1 capsule daily post lunch, with a glass of water or as suggested by your Healthcare Professional.
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SUGGESTED USE
Adults take 1 capsule daily post lunch, with a glass of water.