1. Anti-inflammatory action:

a. Curcumin:

• Studies have demonstrated that Curcumin switches off inflammation at the molecular level by blocking cyclooxygenase-2 (COX-2), an enzyme that makes prostaglandins that are mainly involved in inflammation. [8]

• Curcumin also promoted the synthesis of Cortisol, a hormone that naturally reduces inflammation, and flushes out inflammation-causing toxins out of joints [8].

• Curcumin has been demonstrated to be particularly effective against inflammation arising from Osteoarthritis and Rheumatoid arthritis, tendinitis, ulcerative colitis, and irritable bowel syndrome [9].

b. CoQ10:

• CoQ10 has shown promising results in reducing inflammation, especially in patients recovering from heart treatments.

• CoQ10 lowers levels of interleukin-6 and C-reactive protein, which are markers for cardiac-related inflammation. [10]

• CoQ10 supplementation can significantly reduce inflammation in individuals suffering from coronary artery disease. [10]

2. Antioxidant action:

a. Curcumin:

• Curcumin combats free-radical damage of cells associated with conditions like atherosclerosis and neurodegenerative disorders. [7]

• Curcumin’s role as an antioxidant goes hand-in-hand with its anti-inflammatory action. As an antioxidant, curcumin aids in the prevention of tissue damage and boosts immune function.

b. CoQ10:

• CoQ10 can easily donate electrons to other cells in the body and neutralize free radicals, thus protecting cellular components like lipids, DNA, and protein against free-radical damage. [11]

• The antioxidant mechanism of CoQ10 has also been demonstrated to be highly effective against heart disease [10], immune disorders [4], and periodontal disease [12].

3. Heart protective action:

a. Curcumin:

• Curcumin can prevent the accumulation of oxidized cholesterol in the body, thereby lowering the risk of heart attacks and strokes [13].

• Curcumin’s cardiac protection also extends to heart disease associated with atherosclerosis and diabetes.

• Studies have demonstrated the cholesterol-lowering function of Curcumin. Curcumin signals proteins in the liver to actively flush LDL out of the body-thus, lowering harmful LDL levels in the body [13].

b. CoQ10:

• As an antioxidant and anti-inflammatory, CoQ10 has also been shown to reduce markers associated with cardiac stress and myocardial infarction [10].

• CoQ10 keeps cardiac conditions such as arteriosclerosis, cardiomyopathy, arrhythmia, and hypertension at bay [14].

4. Anti-aging action:

a. Curcumin:

• Curcumin slows down signs of mental aging and lowers the risk of brain degeneration, cognitive decline, and neurodegenerative disorders [7].

• Curcumin reduces signs associated with physiological aging such as arterial stiffness and oxidative stress [15].

• Curcumin boosts the production of collagen, a protein that maintains the elasticity and firmness of the skin [16].

b. CoQ10:

• CoQ10 reverses mitochondrial damage, which can potentially slow down the aging process.
  • CoQ10 is also shown to directly impact the expression of genes that control the aging process, thus controlling the aging process at a genetic level [17].

    References:
    
    4. Gaby, Alan R. "The role of coenzyme Q10 in clinical medicine: Part I." Alt Med Rev 1.1 (1996): 11-17.
    
    7. Cox, Katherine HM, Andrew Pipingas, and Andrew B. Scholey. "Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population." Journal of psychopharmacology 29.5 (2015): 642-651.
    
    8. Akram, Muhammad, et al. "Curcuma longa and curcumin: a review article." Rom J Biol Plant Biol 55.2 (2010): 65-70.
    
    9. Menon, Venugopal P., and Adluri Ram Sudheer. "Antioxidant and anti-inflammatory properties of curcumin." The molecular targets and therapeutic uses of curcumin in health and disease (2007): 105-125.
    
    10. Lee, Bor-Jen, et al. "Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease." Nutrition 28.7-8 (2012): 767-772.
    
    11. Dighe, Nachiket S., et al. "COQ10 A wonder enzyme: A review." Pharma Chem 1.2 (2010): 236-250.
    
    12. Prakash, Shobha, J. Sunitha, and Mayank Hans. "Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases." Indian journal of pharmacology 42.6 (2010): 334.
    
    13. Alwi, Idrus, et al. "The effect of curcumin on lipid level in patients with acute coronary syndrome." Acta Med Indones 40.4 (2008): 201-210.
    
    14. Kumar, Adarsh, et al. "Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome." Pharmacology & therapeutics 124.3 (2009): 259-268.
    
    15. Sikora, E., et al. "The promise of slow down ageing may come from curcumin." Current pharmaceutical design 16.7 (2010): 884-892.
    
    16. Panchatcharam, Manikandan, et al. "Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species." Molecular and cellular biochemistry 290.1 (2006): 87-96.
    
    17. Lina Buchanan, CoQ10: The Longevity Factor hht://www.lef.org/Magazine/2013/1/CoQ10-The-Longevity-Factor/Page-01?checked=1